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Overexpression of microRNA-5100 decreases the aggressive phenotype of pancreatic cancer cells by targeting PODXL.
Chijiiwa Y, Moriyama T, Ohuchida K, Nabae T, Ohtsuka T, Miyasaka Y, Fujita H, Maeyama R, Manabe T, Abe A, Mizuuchi Y, Oda Y, Mizumoto K, Nakamura M. Chijiiwa Y, et al. Int J Oncol. 2016 Apr;48(4):1688-700. doi: 10.3892/ijo.2016.3389. Epub 2016 Feb 12. Int J Oncol. 2016. PMID: 26892887
Silencing PODXL resulted in diminished cell migration (P<0.0001) and invasion (P<0.05). We also clarified the close relationship between expression of PODXL in human pancreatic cancer specimens and liver metastasis (P=0.0003), and determined that post-o …
Silencing PODXL resulted in diminished cell migration (P<0.0001) and invasion (P<0.05). We also clarified the close relationshi …
CTCF-induced upregulation of LINC01207 promotes gastric cancer progression via miR-1301-3p/PODXL axis.
Yu L, Gao Y, Ji B, Feng Z, Li T, Luan W. Yu L, et al. Dig Liver Dis. 2021 Apr;53(4):486-495. doi: 10.1016/j.dld.2020.12.006. Epub 2021 Jan 22. Dig Liver Dis. 2021. PMID: 33495099
Mechanistically, LINC01207 acted as a ceRNA by sponging miR-1301-3p to upregulate PODXL. Besides, miR-1301-3p silencing or PODXL overexpression could abolish the inhibitory effect of LINC01207 knockdown on GC cell growth and migration. ...CONCLUSIONS: CTCF-induced a …
Mechanistically, LINC01207 acted as a ceRNA by sponging miR-1301-3p to upregulate PODXL. Besides, miR-1301-3p silencing or PODXL …
Selective ablation of TRA-1-60+ pluripotent stem cells suppresses tumor growth of prostate cancer.
White JM, Ramos N, Saliganan AD, Chung JY, Bell M, Lindquist J, Conner K, Wiesend WN, Schopperle M, Patrick SM, Kim S, Heath EI, Escorcia FE, Viola NT. White JM, et al. Theranostics. 2023 Mar 27;13(7):2057-2071. doi: 10.7150/thno.78915. eCollection 2023. Theranostics. 2023. PMID: 37153742 Free PMC article.
Experimental Design: First, we assessed the relationship between TRA (PODXL) copy number alterations (CNA) and survival using publicly available patient databases. ...Radiosensitive tissues were collected to assess radiotoxicity while excised tumors were examined for patho …
Experimental Design: First, we assessed the relationship between TRA (PODXL) copy number alterations (CNA) and survival using publicl …
Co-Expression of Ezrin-CLIC5-Podocalyxin Is Associated with Migration and Invasiveness in Hepatocellular Carcinoma.
Flores-Téllez TN, Lopez TV, Vásquez Garzón VR, Villa-Treviño S. Flores-Téllez TN, et al. PLoS One. 2015 Jul 2;10(7):e0131605. doi: 10.1371/journal.pone.0131605. eCollection 2015. PLoS One. 2015. PMID: 26135398 Free PMC article.
Recently, it has been observed that chloride intracellular channel 5 (CLIC5) forms a complex with EZR and PODXL and that it is required for podocyte structure and function. ...CONCLUSION: This study suggested that EZR, CLIC5 and PODXL could be biological markers to …
Recently, it has been observed that chloride intracellular channel 5 (CLIC5) forms a complex with EZR and PODXL and that it is requir …
Podocalyxin enhances breast tumor growth and metastasis and is a target for monoclonal antibody therapy.
Snyder KA, Hughes MR, Hedberg B, Brandon J, Hernaez DC, Bergqvist P, Cruz F, Po K, Graves ML, Turvey ME, Nielsen JS, Wilkins JA, McColl SR, Babcook JS, Roskelley CD, McNagny KM. Snyder KA, et al. Breast Cancer Res. 2015 Mar 27;17(1):46. doi: 10.1186/s13058-015-0562-7. Breast Cancer Res. 2015. PMID: 25887862 Free PMC article.
INTRODUCTION: Podocalyxin (gene name PODXL) is a CD34-related sialomucin implicated in the regulation of cell adhesion, migration and polarity. ...Likewise, in competitive tumor engraftment assays where we injected a 50:50 mixture of control and shPODXL (short-hairpin RNA …
INTRODUCTION: Podocalyxin (gene name PODXL) is a CD34-related sialomucin implicated in the regulation of cell adhesion, migration and …
Methylation of an intronic region regulates miR-199a in testicular tumor malignancy.
Cheung HH, Davis AJ, Lee TL, Pang AL, Nagrani S, Rennert OM, Chan WY. Cheung HH, et al. Oncogene. 2011 Aug 4;30(31):3404-15. doi: 10.1038/onc.2011.60. Epub 2011 Mar 7. Oncogene. 2011. PMID: 21383689 Free PMC article.
We demonstrated PODXL is overexpressed in malignant testicular tumor, and cellular depletion of PODXL resulted in suppression of cancer invasion. The inverse relationship between PODXL and miR-199a-5p expression suggests PODXL is a downstream effector …
We demonstrated PODXL is overexpressed in malignant testicular tumor, and cellular depletion of PODXL resulted in suppression …
Ubiquitous yet distinct expression of podocalyxin on vascular surfaces in normal and tumor tissues in the rat.
Testa JE, Chrastina A, Li Y, Oh P, Schnitzer JE. Testa JE, et al. J Vasc Res. 2009;46(4):311-24. doi: 10.1159/000189792. Epub 2009 Jan 10. J Vasc Res. 2009. PMID: 19142011 Free PMC article.
Western blotting, in vivo imaging and biodistribution analyses demonstrated that the highest levels of endothelial podxl were found in the lung and heart. We also determined that podxl is not enriched in caveolae and that its expression can be modulated in the tumor …
Western blotting, in vivo imaging and biodistribution analyses demonstrated that the highest levels of endothelial podxl were found i …
In-depth characterization of the secretome of colorectal cancer metastatic cells identifies key proteins in cell adhesion, migration, and invasion.
Barderas R, Mendes M, Torres S, Bartolomé RA, López-Lucendo M, Villar-Vázquez R, Peláez-García A, Fuente E, Bonilla F, Casal JI. Barderas R, et al. Mol Cell Proteomics. 2013 Jun;12(6):1602-20. doi: 10.1074/mcp.M112.022848. Epub 2013 Feb 26. Mol Cell Proteomics. 2013. PMID: 23443137 Free PMC article.
Liver metastasis in colorectal cancer is the major cause of cancer-related deaths. ...In addition, silencing of SOSTDC1, EFNA3, and CD137L/TNFSF9 reduced liver colonization capacity of KM12SM cells. Finally, the panel of six proteins involved in invasion showed asso …
Liver metastasis in colorectal cancer is the major cause of cancer-related deaths. ...In addition, silencing of SOSTDC1, EFNA3, and C …
Annexin A10 optimally differentiates between intrahepatic cholangiocarcinoma and hepatic metastases of pancreatic ductal adenocarcinoma: a comparative study of immunohistochemical markers and panels.
Kälsch J, Padden J, Bertram S, Pott LL, Reis H, Westerwick D, Schaefer CM, Sowa JP, Möllmann D, Fingas C, Dechȇne A, Sitek B, Eisenacher M, Canbay A, Ahrens M, Baba HA. Kälsch J, et al. Virchows Arch. 2017 May;470(5):537-543. doi: 10.1007/s00428-017-2114-2. Epub 2017 Mar 29. Virchows Arch. 2017. PMID: 28357490
In a training set of 87 ICC and 88 pPDAC, our previously identified biomarkers Annexin A1 (ANXA1), ANXA10, and ANXA13 were tested and compared with 11 published biomarkers or panels (MUCIN 1, Agrin, S100P, MUC5 AC, Laminin, VHL, CK 17, N-Cadherin, ELAC2, PODXL and HSPG2). …
In a training set of 87 ICC and 88 pPDAC, our previously identified biomarkers Annexin A1 (ANXA1), ANXA10, and ANXA13 were tested and compar …
Podocalyxin-like protein 1 expression is useful to differentiate pancreatic ductal adenocarcinomas from adenocarcinomas of the biliary and gastrointestinal tracts.
Ney JT, Zhou H, Sipos B, Büttner R, Chen X, Klöppel G, Gütgemann I. Ney JT, et al. Hum Pathol. 2007 Feb;38(2):359-64. doi: 10.1016/j.humpath.2006.08.025. Epub 2006 Nov 29. Hum Pathol. 2007. PMID: 17137615
When used as a differential diagnostic marker, ampullary carcinoma needs to be excluded, as 30% (6/20, P = .24) of ampullary carcinomas stain positive, especially those of the signet-ring type (3/3). Adenocarcinomas of the lung and prostate, and liver metastases of colorec …
When used as a differential diagnostic marker, ampullary carcinoma needs to be excluded, as 30% (6/20, P = .24) of ampullary carcinomas stai …
11 results